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Tuesday, February 10, 2009

HARAGOBIND KHURANA

HARAGOBIND KHURANA
(B.1922)

Haragobind Khurana, the Indian Scientist is the third Indian who won Nobel Prize in the field of physiology and medicine in 1968. He shared it with Robert W.Holley and Marshall W.Nirenberg for interpretation of the genetic code and its function in protein synthesis.

Khurana was born on Jan 2, 1922 at Rajpur in Punjab. He was the son of a village tax collector. The family was illiterate in the entire village. But khurana studied well and passed degree examination from Lahore college. He took post graduate degree in chemistry in 1945 from Punjab university. Then he went to Manchester University for higher studies. He obtained his doctorate degree in 1948. On his return to India, he was disappointed. He could not get a job for many months. He went back to England and worked with Nobel Laureate Sir Alexander Todd at Cambridge University. In 1952 he went to Canada and married the daughter of M.P.Switzerland.

Khurana helped to decipher the Genetic Code by recreating Synthetically each of the 64 possible triplets of DNA (De onyribo nucleic acid) which work in combination as instructions for the protein synthesizing mechanism of the cell. He succeeded in Synthesizing the first wholly artificial gene. It was E.coli or Escherichia coli.

E.Coli is a bacteria that lives in the intestines of human beings and animals. Khorana and his team worked to build a gene of this organism. Piece by Piece they built up the 207 genes of this bacteria. In August 1976, the man made gene was inserted into E.Coli which began to work like the natural gene. Khorana’s achievements made available a technique to change genes and observe the results of those changes.

Khorana is the recipient of many awards. To mention a few he has been given Merch award of the chemical institute of Canada, Gold medal of the professional institute of Canadian public service, Dannie Heineman prize, Lasker foundation award and Louis Horutiz prize.

Khorana has published more than 300 papers on genetic research. He is Padma Bhushan.

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